World Health Organization report 'Key criteria for the ethical acceptability of COVID-19 human challenge studies' cites papers by Julian Savulescu, Tom Douglas, Hannah Maslen and Alberto Giubilini.
Controlled human challenge studies involves the deliberate infection of healthy volunteers. They are particularly useful for testing multiple vaccine candidates quickly and efficiently, as well as providing data on the processes of transmission, infection and immunity.
Aimed at scientists, policy-makers and regulators, the report outlines the criteria that would need to be met for human challenge studies on COVID-19 to be ethically acceptable.
Click here to read report (6 May 2020).
OUC papers cited:
Schaefer G, Tam CC, Savulescu J, Voo TC. Covid-19 vaccine development: time to consider Sars-Cov-2 challenge studies? SSRN Electronic Journal. January 2020.
https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3568981 - SSRN REGISTRATION REQUIRED (FREE)
Bambery B, Douglas T, Selgelid MJ, Maslen H, Giubilini A, Pollard AJ et al. Influenza vaccination strategies should target children. Public Health Ethics.
2018;11(2):221–34.
https://academic.oup.com/phe/article/11/2/221/4716924?searchresult=1 - OPEN ACCESS
Bambery B, Selgelid M, Weijer C, Savulescu J, Pollard AJ. Ethical criteria for human challenge studies in infectious diseases. Public Health Ethics. 2015;9(1):92–103.
https://academic.oup.com/phe/article/9/1/92/2362760 - FREE
